In early February, Merck proposed a buyout at a price of $40 per share, which it revised two days later to $50 per share. The Motley Fool has a disclosure policy. This has been avoided, but the refining was done on January the 3rd, so it takes at least until February the 3rd before HSR runs out. Opiant Pharmaceuticals, Inc. ( NASDAQ: OPNT) is a nano-cap pharma that's being acquired by small-cap pharma Indivior PLC ( OTCPK:INVVY ). 2000-2023 Investor's Business Daily, LLC. Pandion refused and continued discussions with another company that showed interest, but never progressed to making an offer. Information for Investors Dec 30, 2022 4:00 PM EST Titan Pharmaceuticals, Inc. Nasdaq: TTNP $0.7831 0.0071 Volume 133.97k Day 0.73 - 0.80 52-Week 0.35 - 1.59 Average Volume 0 January 3, 2023 A Look Back at Sciences 2022 Breakthroughs Read Article December 20, 2022 Celebrating the Power of Connection This Holiday Season Read Article Read Article Sign up for free newsletters and get more CNBC delivered to your inbox. The drug is responsible for most of GW Pharmaceutical's revenue, including $132.6 million of the company's reported $137.1 million third-quarter sales. They just approach similar diseases with different therapies. On today's stock market, AUPH stock toppled 9.4% to 10.49. When you look at the fact that Jazz is expected to grow earnings at a near-25% annualized rate over the next half decade, its hard not to like the pharma companys prospects. many of the major pharma companies might need to. *Average returns of all recommendations since inception. Indivior is laying out $20 in cash and a contingent value right that's potentially worth up to $8 per share. Thats because their growth is declining as major drug patents expire; they need to turn to acquisitions to help jump-start growth. That's not to say that Axsome can't turn Auvelity into a commercial success, but the path of least resistance is definitely the buyout route. It's not likely to go any higher than that $7. This isn't likely to be a killer acquisition that regulators don't like. The companies had to withdraw and refile under Hart-Scott-Rodino, or HSR. The top ten deals in the industry totaled $97 billion in 2020, led by the $39-billion buyout of Alexion Pharmaceuticals - Get Free Report late in the year by AstraZeneca - Get What Will Make Miners Reclaim Their Luster? 1-trusted industry spot in Ipsos just-released annual survey. Cost basis and return based on previous market day close. Another example of a big deal struck at a huge premium wasAlexions $8.4bn takeout of Synageva in 2015, at a 127% premium. The oral spray, which contains both CBD and THC, is already approved in the U.K. as a therapy for various multiple sclerosis (MS) symptoms, especially MS-related spasticity (muscle spasms or stiffness). Namely, Alnylam's shares are already trading at close to 16 times 2023 projected sales. Puoi cambiare le tue preferenze in qualunque momento nella sezione Le tue impostazioni per la privacy. Epidiolex is used to treat seizures associated with Lennox-Gastaut syndrome or Dravet syndrome, two rare forms of epilepsy. Not so for Synthorx and Spark, the takeovers of which were presumably competitive processes. Rather, it is choosing to wait for the right opportunity. Get stock recommendations, portfolio guidance, and more from The Motley Fool's premium services. However, on May 25 of the same year, Guidant reported 26 cases of implantable defibrillator failure, including a death. I am not receiving compensation for it (other than from Seeking Alpha). The company has gone from making a Watch these two pharma companies with big buyout potential: Endo just completed the $2.6 billion buyout of Auxilium Pharmaceuticals, which has two branded testosterone products. So why the sudden interest in buying up smaller pharma companies? Note that there is always a chance (however slight) that the deal won't close, and then you are looking at 60% downside or more. The suit was filed just before Christmas in a federal court in Waco, Texas. The biotech also sports five late-stage clinical candidates. Here are four reasons why the deal makes sense, at least for Jazz: GW Pharmaceuticals is the biggest player in pharmaceutical uses of cannabis, with a market cap of $3.9 billion, making it the sixth-largest marijuana-related stock in the world. Merck, under outgoing CEO Ken Frazierand now retired research chief Roger Perlmutter, has stayed away from large-scale dealmaking. The bottom line is that Karuna is unlikely to remain independent leading into KarXT's upcoming regulatory filing in mid-2023. Novartis ADR sees its Relative Strength Rating reach the 80-plus Get instant access to exclusive stock lists, expert market analysis and powerful tools with 2 months of IBD Digital for only $20! These three companies sport highly attractive assets, making them top-tier targets for big pharma. Treatments for overdoses (Opiant pharmaceuticals). In truth, many of the major pharma companies might need to buy some growth. Per maggiori informazioni sulle modalit di utilizzo dei dati, consulta la nostra Informativa sulla privacy e lInformativa sui cookie. The following table lists the largest mergers and acquisitions in the pharmaceutical and biotechnology industry (those over $10 billion). The biggest premium paid over the period was actually for Tobira, which Allergan bought for $1.7bn in 2016, at a 1,532% 30-day premium; however, this has been excluded as an outlier. George Budwell has positions in Axsome Therapeutics. Through nine months, it lost $28,981 million in net income, compared to positive net income of $15 million in the same period in 2019. Johnson & Johnson announced that it was acquiring Guidant on December 15, 2004, for $76 a share, with the deal being approved later approved on April 27, 2005 by Guidant shareholders. That's if we simplify the situation to assume the merger closes. The company has remained resilient during the M&A boom in pharma, refraining from making recklessacquisitions. List of largest pharmaceutical mergers and acquisitions, GlaxoSmithKlineNovartis Consumer Healthcare, "FirstWord Lists The 20 largest pharma M&A deals", Bristol-Myers set $2.2 billion termination fee for their mega deal, "Allergan Accelerates Transformation to Branded Growth Pharma Leader by Divesting Global Generics Business to Teva for $40.5 Billion", "Teva CEO: $40.5 Billion Allergan Deal is Just the Beginning", "Teva Snaps Up Allergan's Generics Arm, Dumping Mylan", "Pfizer And Allergan Merger Ranks As Biggest-Ever Pharmaceutical Deal", "Japan's Takeda clinches 45.3 billion Shire deal as pharma M&A rolls on", "FirstWord Lists The 20 largest pharma M&Adeals", "Pfizer Ends $160B Acquisition of Allergan after U.S. After the re-negotiated a lower price of $21.5 billion was trumped by Boston Scientifics offer of $24.6 billion, Johnson & Johnson raised their offer to $23.2 billion. If you can get them cheap enough, they can be really attractive. Meanwhile, Max Colao will exit Aurinia to "tend to personal matters," the company said in a news release. Sign up for free today. I think of the two, Jazz is the better buy today. Opiant pharmaceutical (Opiant presentation). This happens a lot when pharma or biotech companies with important unapproved assets get bought. - Pfizer: One of the world's premier biopharmaceutical companies", "American Home Products Discusses A Merger With Warner-Lambert", "Bayer sweetens Monsanto bid as talks enter final stretch", "Statement re Proposal from Takeda Pharmaceutical Company Limited", "Allergan agrees to $66 billion Actavis offer; Valeant walks", "Valeant Raises Takeover Offer for Allergan a Second Time", "Valeant Raises Takeover Offer for Allergan With More Cash", "Monsanto Drops $46.5B Bid For Syngenta, Paving Way For Stock Buyback Amid Market Rout", "Syngenta rejects Monsanto's takeover approach", "Reuters: Monsanto, Syngenta hire U.S. banks to advise on possible takeover", "Valeant, Bill Ackman bid $45B for Botox-maker Allergan", "Monsanto Said to Have Weighed $40 Billion Syngenta Deal", "Teva Offers to Buy Mylan in $40.1B Cash-And-Stock Deal", "Endo Ends Effort to Wrest Merger-Bound Salix from Valeant - GEN Genetic Engineering & Biotechnology News - Biotech from Bench to Business - GEN", https://en.wikipedia.org/w/index.php?title=List_of_largest_pharmaceutical_mergers_and_acquisitions&oldid=1077126324, Lists of corporate mergers and acquisitions, Articles with dead external links from July 2021, Short description is different from Wikidata, Articles with unsourced statements from June 2019, Creative Commons Attribution-ShareAlike License 3.0, In November 2015 Pfizer announced it would acquire. Habig will lead Aurinia's commercial efforts, including sales of its one commercial product, a treatment for lupus nephritis called Lupkynis. Tobira had suffered a big clinical setback before Allergan swooped, and was actually bought for a historically depressed price, despite the high premium. Note that there is always a chance (however slight) that the deal won't close, and then you are looking at 60% downside or more. In late September, Pandion's CEO, top scientist, board chairman and head of business development all sat down with Merck's Perlmutter, who was eager to see early-stage data for PT-101. Why is Alnylam a possible takeover target? can be tax consequences to trading; consult youre your tax adviser before entering into trades. Knappertz comes to Aurinia from GW Pharmaceuticals. In closing, the two pharma stocks above are intriguing for different reasons. February started off with Pfizer (NYSE: PFE) buying up Hospira (NYSE: HSP) for $15 billion. Sanofi earlier this year completed the GW Pharmaceuticals is the biggest player in pharmaceutical uses of cannabis, with a market cap of $3.9 billion, making it the sixth-largest marijuana-related stock in the world. In a report earlier this month, RBC OPNT also has financial backing and collaborates with U.S. government agencies, which is a soft sign that there is at least governmental/societal interest in getting its product out there. Amgen spent $3.7 billion on a deal earlier this month for ChemoCentryx in order to attain the newly approved ANCA-associated vasculitis drug Tavneos. Axsome's buyout thesis truly centers around Auvelity, however. I wrote this article myself, and it expresses my own opinions. The Motley Fool has positions in and recommends Alnylam Pharmaceuticals, Axsome Therapeutics, Merck & Co., and Seagen Inc. Price as of January 18, 2023, 1:06 p.m. Dati relativi al dispositivo e alla connessione a Internet, come l'indirizzo IP, Attivit di navigazione e di ricerca durante l'utilizzo dei siti web e delle app di Yahoo. 2. advised that this publication is issued solely for informational purposes and should not be construed as an Disclosure: I/we have a beneficial long position in the shares of OPNT either through stock ownership, options, or other derivatives. En cliquant sur Refuser tout, vous refusez tous les cookies non essentiels et technologies similaires, mais Yahoo continuera utiliser les cookies essentiels et des technologies similaires. Learn More. After all, the richest deals in this space have generally come in at around six to eight times peak estimated revenue. 2023 CNBC LLC. The oral solution is the only cannabidiol (CBD) approved as a therapy by the FDA. The huge sums of money flowing into drug development, and the resulting surge in valuations, has meant only one thing for industry buyers: soaring price tags. The pharmaceutical merger and acquisition (M&A) scene is heating up. For Get the free daily newsletter read by industry experts. Without the acquirer, that becomes a lot more challenging. Merck's paid a high price for several of those deals, too, agreeing to pay a more than 300% premium for Immune Design in 2019, a 107% premium for ArQulethat same year and, last month, a 140% premium for Pandion. Novartis ADR sees its Relative Strength Rating reach the 80-plus level. Merck's first attempt was in late January 2020, when the pharma offered Pandion $65 million upfront to acquire the biotech's research, including its most advanced drug candidate at the time, PT-101. All Rights Reserved. A Division of NBCUniversal. But takeover talk has largely cooled down since late last year. Almost all of Indivior's assets are focused on treating addiction. I'm interested in what quants do, options traders do, and even what WallStreetBets is doing (keep your friends close and). About half of adults with lupus will develop lupus nephritis. Jazz's focus on oncology and sleep disorder could also be helped by GW Pharmaceutical's cannabis expertise. First bid, unanimously rejected by the Shire Board, who concluded that it significantly undervalue the Company, its growth prospects as well as pipeline. Time to Buy? Follow me on Twitter @Bramdehaas or email me Dehaas.Bram at Gmail. Dr. Rahul Gupta, head of the White House Office of National Drug Control Policy, points out that last year alone, 80,000 Americans died from opioid overdoses. Please be aware of the risks associated with these stocks. In 2013, industry-watchers speculated that Endo could be a Valeant buyout target. click here for our full report on this opportunity. oth are in the sweet spot of pharma buyouts, trading with market caps between $10 billion and $15 billion. Annual revenues from cannabinoid-based pharmaceuticals are expected to grow to $50 billion by 2029, according to Statista Research. Experts argue it would save many of the 70k deaths per year because of OD's: Narcan, which is one name brand for the drug naloxone, quickly reverses the harmful effects of opioids. There are all kinds of expensive research reports floating around that estimate the Naxolone spray market at $1.1 billion already or that project growth to $1.94 billion by 2028 or $1.3 billion in 2031. 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